Journal:
Article Title: STAT1 Is Essential for Antimicrobial Effector Function but Dispensable for Gamma Interferon Production during Toxoplasma gondii Infection
doi: 10.1128/IAI.72.3.1257-1264.2004
Figure Lengend Snippet: STAT1−/− mice are highly susceptible to T. gondii infection. (A) STAT1−/− mice die by 10 days postinfection with 20 ME49 cysts, while WT 129Sv/Ev mice survive infection until termination of the experiment at 30 days. Data are representative of two independent experiments with 10 mice per group. (B) Increased parasitemia in macrophages of infected STAT1−/− mice. Peritoneal exudate cells were recovered at 0, 4, and 7 days postinfection, and the percentage of infected macrophages was determined at 4 and 7 days postinfection. Student's t test revealed statistically significant differences between WT (solid bars) and KO (open bars) samples (*, P = 0.008; and **, P = 0.014). Data were pooled from two independent experiments with three mice per group; bars represent standard error.
Article Snippet: Wild-type (WT) mice of the 129Sv/Ev strain were purchased from Taconic (Germantown, N.Y.).
Techniques: Infection